The GestAssured™ test is a rapid diagnostic test for preeclampsia that is currently in development.
This novel test is based on research led by two doctors seeking tools for diagnosing preeclampsia. They discovered protein that is misfolded and aggregated in urine of women who have preeclampsia. Research has shown a strong correlation between preeclampsia and the presence of these misfolded proteins.1-3 Detecting these proteins in urine during a diagnostic workup could provide clarity in the diagnosis of preeclampsia and improve patient management.
The GestAssured™ test is designed to be a cost-effective, easy-to-use test that fits into the existing clinical workflow. The GestAssured™ test will provide objective, reproducible, preeclampsia-specific information for use by clinicians in conjunction with existing diagnostic directives.
Kara Rood, Catalin S. Buhimschi, Theresa Dible, Shaylyn Webster, Guomao Zhao, Philip Samuels, and Irina A. Buhimschi. Point-of-care congo red dot (CRD) test for antenatal triage and rapid identification of preeclampsia (PE). Am J Obstet Gynecol. Supplement to 2016 Jan: S24.
Irina A. Buhimschi, Unzila A. Nayeri, Guomao Zhao, Lydia L. Shook, Anna Pensalfini, Edmund F. Funai, Ira M. Bernstein, Charles G. Glabe and Catalin S. Buhimschi. Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia. Sci Transl Med. 2014 Jul 16;6(245):245ra92.PMID: 25031267; DOI: 10.1126/scitranslmed.3008808
Irina A. Buhimschi, Guomao Zhao, Edmund F. Funai, Nathan Harris, Isaac E. Sasson, Ira M. Bernstein, George R. Saade, and Catalin S. Buhimschi. Proteomic profiling of urine identifies specific fragments of SERPINA1 and albumin as biomarkers of preeclampsia. Am J Obstet Gynecol. 2008 Nov;199(5):551.e1-16.PMID: 18984079; PMCID: PMC2679897; DOI: 10.1016/j.ajog.2008.07.006